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Article

GFAP Alternative Splicing and the Relevance for Disease – A Focus on Diffuse Gliomas

1 Jan 2022

Abstract excerpt

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma. Since the discovery of the protein 50 years ago, multiple alternative splice variants of the GFAP gene have been discovered, leading to different GFAP isoforms. In this review, we will describe GFAP isoform expression from gene to protein...

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PMID: 35673702
DOI: 10.1177/17590914221102065

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