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Article

Glial fibrillary acidic protein is pathologically modified in Alexander disease.

The Journal of biological chemistry - 1 Jul 2024

Lin Ni-Hsuan, Jian Wan-Syuan, Snider Natasha, Perng Ming-Der

Abstract excerpt

Here, we describe pathological events potentially involved in the disease pathogenesis of Alexander disease (AxD). This is a primary genetic disorder of astrocyte caused by dominant gain-of-function mutations in the gene coding for an intermediate filament protein glial fibrillary acidic protein (GFAP). Pathologically, this disease is characterized by the upregulation of GFAP and its accumulation as Rosenthal...

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Identifiers

PMID: 38782207
DOI: 10.1016/j.jbc.2024.107402
PMCID: PMC11259701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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