Article
Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin.
Antimicrobial agents and chemotherapy - 1 Jan 2014
Dahlström Sabina, Aubouy Agnès, Maïga-Ascofaré Oumou, Faucher Jean-François, Wakpo Abel, Ezinmègnon Sèm, Massougbodji Achille, Houzé Pascal, Kendjo Eric, Deloron Philippe, Le Bras Jacques, Houzé Sandrine
Abstract excerpt
Artemisinin-based combination therapies (ACTs) are the main option to treat malaria, and their efficacy and susceptibility must be closely monitored to avoid resistance. We assessed the association of Plasmodium falciparum polymorphisms and ex vivo drug susceptibility with clinical effectiveness....
Topics
- Amodiaquine
- Antimalarials
- Artemisinins
- Drug Combinations
- Ethanolamines
- Female
- Fluorenes
- Humans
- Inhibitory Concentration 50
- Lumefantrine
- Male
- Mefloquine
- Membrane Transport Proteins