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Article

Low prevalence of highly sulfadoxine-resistant dihydropteroate synthase alleles in Plasmodium falciparum isolates in Benin.

Malaria journal - 5 Feb 2021

Svigel Samaly Souza, Adeothy Adicath, Kpemasse Augustin, Houngbo Ernest, Sianou Antoine, Saliou Ramani, Patton Monica E, Dagnon Fortune, Halsey Eric S, Tchevoede Alexis, Udhayakumar Venkatachalam, Lucchi Naomi W

Abstract excerpt

BACKGROUND: In 2004, in response to high levels of treatment failure associated with sulfadoxine-pyrimethamine (SP) resistance, Benin changed its first-line malaria treatment from SP to artemisinin-based combination therapy for treatment of uncomplicated Plasmodium falciparum malaria. Resistance to SP is conferred by accumulation of single nucleotide polymorphisms (SNPs) in P. falciparum genes involved in folate...

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Identifiers

PMID: 33546703
DOI: 10.1186/s12936-021-03605-5
PMCID: PMC7866691

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