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Article

Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2.

PloS one - 1 Jan 2013

Wiesner Diana, Merdian Irma, Lewerenz Jan, Ludolph Albert C, Dupuis Luc, Witting Anke

Abstract excerpt

Fumaric acid esters (FAE) are oral analogs of fumarate that have recently been shown to decrease relapse rate and disease progression in multiple sclerosis (MS), prompting to investigate their protective potential in other neurological diseases such as amyotrophic lateral sclerosis (ALS). Despite efficacy in MS, mechanisms of action of FAEs are still largely unknown. FAEs are known to activate the transcription...

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Identifiers

PMID: 24098549
DOI: 10.1371/journal.pone.0076670
PMCID: PMC3789659

Genes

KEAP1
SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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