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Hyperexpanded CD4 <sup>+</sup> T cell clones in rheumatoid arthritis show attenuated senescence and accumulate in afflicted joints

2026-07-10

Abstract excerpt

<h4>Objective</h4> Clonal hyperexpansion of CD4 + T cells is a characteristic feature of rheumatoid arthritis (RA). Equally large T cell clones also arise in physiological ageing or latent viral infection and adopt a replicative senescence programme – a tolerance mechanism that limits immune activation by innate-like reprogramming and proliferative arrest. We aimed to characterise the senescence programme of hyp...

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Literature Corpus work
16f5eedc-bfcf-545f-b2d2-3758628b426d
DOI
10.64898/2026.07.09.26357637
Open publication

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Hyperexpanded CD4 <sup>+</sup> T cell clones in rheumatoid arthritis show attenuated senescence and accumulate in afflicted jointsDOI 10.64898/2026.07.09.26357637
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