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Article

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.

Nature immunology - 1 Nov 2013

Lee You Jeong, Holzapfel Keli L, Zhu Jinfang, Jameson Stephen C, Hogquist Kristin A

Abstract excerpt

Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4 (IL-4) early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we have defined three subsets of iNKT cells (NKT1, NKT2 and NKT17) that produced distinct cytokines; these represented diverse...

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PMID: 24097110
DOI: 10.1038/ni.2731
PMCID: PMC3824254

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