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Article

Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice.

Gastroenterology - 1 Aug 2012

Wingender Gerhard, Stepniak Dariusz, Krebs Philippe, Lin Lin, McBride Sara, Wei Bo, Braun Jonathan, Mazmanian Sarkis K, Kronenberg Mitchell

Abstract excerpt

BACKGROUND & AIMS: Invariant natural killer T (iNKT) cells undergo canonical, Vα14-Jα18 rearrangement of the T-cell receptor (TCR) in mice; this form of the TCR recognizes glycolipids presented by CD1d. iNKT cells mediate many different immune reactions. Their constitutive activated and memory phenotype and rapid initiation of effector functions after stimulation indicate previous antigen-specific stimulation....

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Identifiers

PMID: 22522092
DOI: 10.1053/j.gastro.2012.04.017
PMCID: PMC3404247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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