Article
Durable Control of Metastatic AKT1-Mutant WHO Grade 1 Meningothelial Meningioma by the AKT Inhibitor, AZD5363.
Journal of the National Cancer Institute - 1 Mar 2017
Weller Michael, Roth Patrick, Sahm Felix, Burghardt Isabel, Schuknecht Bernhard, Rushing Elisabeth J, Regli Luca, Lindemann Justin P, von Deimling Andreas
Abstract excerpt
High-throughput analyses have revealed the presence of activating mutations in the AKT1 gene in a subpopulation of meningiomas. We report a female patient with multiple intracranial tumor manifestations and histologically verified meningotheliomatous meningioma in the lung. The tumor was continuously growing at multiple sites despite six surgical resections, radiotherapy, and two lines of systemic therapy....
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