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Article

Multiomics reveals the mechanism of KNG1 in promoting tumor progression in adamantinomatous craniopharyngioma.

Journal of neuro-oncology - 5 Jan 2026

Zhou Lin, Xu Zhicheng, Fang Chao, Ren Hui, Yang Chenxing, Wang Zhigang, Hong Tao, Wu Jie

Abstract excerpt

PURPOSE: Adamantinomatous craniopharyngioma (ACP) are rare and histologically benign but clinically challenging neoplasms. The aim of this study was to investigate the molecular genetic and proteomic alterations in the tumor to identify potential therapeutic targets for ACP. METHODS: Sanger sequencing characterized mutations in 20 craniopharyngiomas. Serum proteomics by iTRAQ-based LC-MS/MS compared ACP patients...

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Source

Identifiers

PMID: 41489673
DOI: 10.1007/s11060-025-05406-1

Genes

KNG1
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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