Article
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors.
BMC cancer - 5 Oct 2013
Klajic Jovana, Fleischer Thomas, Dejeux Emelyne, Edvardsen Hege, Warnberg Fredrik, Bukholm Ida, Lønning Per Eystein, Solvang Hiroko, Børresen-Dale Anne-Lise, Tost Jörg, Kristensen Vessela N
Abstract excerpt
BACKGROUND: Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation patterns in order to identify valuable markers to understand how these changes affect breast cancer progression. METHODS: Quantitative DNA methylation analyses of 12 candidate genes ABCB1,...
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