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Article

Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer.

Genome medicine - 29 Apr 2021

Aure Miriam Ragle, Fleischer Thomas, Bjørklund Sunniva, Ankill Jørgen, Castro-Mondragon Jaime A, Børresen-Dale Anne-Lise, Tost Jörg, Sahlberg Kristine K, Mathelier Anthony, Tekpli Xavier, Kristensen Vessela N

Abstract excerpt

BACKGROUND: Abnormal DNA methylation is observed as an early event in breast carcinogenesis. However, how such alterations arise is still poorly understood. microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and play key roles in various biological processes. Here, we integrate miRNA expression and DNA methylation at CpGs to study how miRNAs may affect the breast cancer methylome and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33926515
DOI: 10.1186/s13073-021-00880-4
PMCID: PMC8086068

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