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Article

Evolution of HIV-1 coreceptor usage and coreceptor switching during pregnancy.

AIDS research and human retroviruses - 1 Mar 2014

Ransy Doris G, Motorina Alena, Merindol Natacha, Akouamba Bertine S, Samson Johanne, Lie Yolanda, Napolitano Laura A, Lapointe Normand, Boucher Marc, Soudeyns Hugo

Abstract excerpt

Coreceptor switch from CCR5 to CXCR4 is associated with HIV disease progression. To document the evolution of coreceptor tropism during pregnancy, a longitudinal study of envelope gene sequences was performed in a group of pregnant women infected with HIV-1 of clade B (n=10) or non-B (n=9). Polymerase chain reaction (PCR) amplification of the V1-V3 region was performed on plasma viral RNA, followed by cloning and...

Read the complete abstract on PubMed

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Share to env Gene Products, Human Immunodeficiency Virus
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Longitudinal Studies

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Share to Pregnancy Complications, Infectious

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Source

Open in PubMed Open full text

Identifiers

PMID: 24090041
DOI: 10.1089/aid.2013.0155
PMCID: PMC3938935

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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