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Article

Evolution of coreceptor utilization to escape CCR5 antagonist therapy.

Virology - 1 Jul 2016

Zhang Jie, Gao Xiang, Martin John, Rosa Bruce, Chen Zheng, Mitreva Makedonka, Henrich Timothy, Kuritzkes Daniel, Ratner Lee

Abstract excerpt

The HIV-1 envelope interacts with coreceptors CCR5 and CXCR4 in a dynamic, multi-step process, its molecular details not clearly delineated. Use of CCR5 antagonists results in tropism shift and therapeutic failure. Here we describe a novel approach using full-length patient-derived gp160 quasispecies libraries cloned into HIV-1 molecular clones, their separation based on phenotypic tropism in vitro, and deep...

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Topics

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Share to Anti-HIV Agents
Share to CCR5 Receptor Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Envelope Protein gp120

Share to Position-Specific Scoring Matrices

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 27128349
DOI: 10.1016/j.virol.2016.04.010
PMCID: PMC4913893

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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