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Article

HIV-1 Coreceptor Usage, Transmission, and Disease Progression

1 Apr 2003

Abstract excerpt

HIV-1 coreceptor usage is believed to play a critical role in pathogenesis. To initiate infection, HIV-1 interacts with two cell surface receptors; CD4 is the primary receptor and the beta-chemokine receptors CCR5 and CXCR4 usually serve as secondary receptors. HIV-1 strains transmitted in vivo generally use CCR5. Viruses that use CCR5 (R5 viruses) appear to be associated with relatively stable infection. Years...

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Identifiers

PMID: 15043204
DOI: 10.2174/1570162033485357

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Source receipt: pubmed, retrieved 7 Sept 2026.

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