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Article

Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies.

Molecular biology reports - 1 Feb 2012

Han Dong, Shen Chao, Meng Xiangning, Bai Jing, Chen Feng, Yu Yang, Jin Yan, Fu Songbin

Abstract excerpt

Methionine synthase reductase (MTRR) gene is involved in tumorigenesis by regulating DNA methylation through activation of methionine synthase (MTR). MTRR is polymorphic at nucleotide 66 (A-to-G) and the resulting variant enzyme has a lower affinity for MTR. The reported associations of MTRR A66G polymorphism with cancer risk are contradictory. Therefore, we performed a meta-analysis to better assess the...

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Source

Identifiers

PMID: 21547363
DOI: 10.1007/s11033-011-0802-6

Genes

MTRR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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