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Article

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.

Integrative biology : quantitative biosciences from nano to macro - 1 Nov 2013

Lau Ken S, Schrier Sarah B, Gierut Jessica, Lyons Jesse, Lauffenburger Douglas A, Haigis Kevin M

Abstract excerpt

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine that can elicit distinct cellular behaviors under different molecular contexts. Mitogen activated protein kinase (MAPK) pathways, especially the extracellular signal-regulated kinase (Erk) pathway, help to integrate influences from the environmental context, and therefore modulate the phenotypic effect of TNF-α exposure. To test how variations in...

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Share to Epithelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Share to Proto-Oncogene Proteins c-akt

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Source

Open in PubMed Open full text

Identifiers

PMID: 24084984
DOI: 10.1039/c3ib40062j
PMCID: PMC3966991

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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