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Article

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

PLoS biology - 1 Jan 2012

Lau Ken S, Cortez-Retamozo Virna, Philips Sarah R, Pittet Mikael J, Lauffenburger Douglas A, Haigis Kevin M

Abstract excerpt

Intestinal epithelial cells exist within a complex environment that affects how they interpret and respond to stimuli. We have applied a multi-scale in vivo systems approach to understand how intestinal immune cells communicate with epithelial cells to regulate responses to inflammatory signals. Multivariate modeling analysis of a large dataset composed of phospho-signals, cytokines, and immune cell populations...

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Identifiers

PMID: 23055830
DOI: 10.1371/journal.pbio.1001393
PMCID: PMC3463506

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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