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Elevated CO <sub>2</sub> levels affect development, motility, and fertility and extend life span in <i>Caenorhabditis elegans</i>

23 Feb 2009

Abstract excerpt

Hypercapnia (high CO(2) levels) occurs in a number of lung diseases and it is associated with worse outcomes in patients with chronic obstructive lung disease (COPD). However, it is largely unknown how hypercapnia is sensed and responds in nonneuronal cells. Here, we used C. elegans to study the response to nonanesthetic CO(2) levels and show that levels exceeding 9% induce aberrant motility that is accompanied...

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PMID: 19237558
DOI: 10.1073/pnas.0900309106

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