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Article

No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese.

Neuroscience letters - 30 Apr 2014

Li Xiao, Zhang Wen, Zhang Chen, Gong Wei, Tang Jinsong, Yi Zhenghui, Wang Dong, Lu Weihong, Fang Yiru, Chen Xiaogang, Yao Yong-Gang

Abstract excerpt

Mitochondrial dysfunction was widely reported in schizophrenia patients in recent studies. Leucine-rich repeat kinase 2 (LRRK2) is a mitochondrial protein, and mutations in the LRRK2 gene can induce mitochondrial dysfunction. LRRK2 mutations have been reported to be the most frequent genetic cause of Parkinson's disease (PD). We were interested in whether LRRK2 variants also play a role in schizophrenia. In this...

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PMID: 24631561
DOI: 10.1016/j.neulet.2014.03.006

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