Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.

Blood - 1 Jan 2007

Talebian Laleh, Li Zhe, Guo Yalin, Gaudet Justin, Speck Maren E, Sugiyama Daisuke, Kaur Prabhjot, Pear Warren S, Maillard Ivan, Speck Nancy A

Abstract excerpt

The family of core-binding factors includes the DNA-binding subunits Runx1-3 and their common non-DNA-binding partner CBFbeta. We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series. Reducing CBFbeta levels by 3- or 6-fold caused abnormalities in bone development, megakaryocytes, granulocytes, and T cells. T-cell development was very sensitive to an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Development
Share to Colony-Forming Units Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocytes

Share to Hematopoiesis

Share to Megakaryocytes

Share to Radiation Chimera

Share to T-Lymphocyte Subsets

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 16940420
DOI: 10.1182/blood-2006-05-021188
PMCID: PMC1785070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.PMID 16940420Read ↗

Core binding factor and its role in normal hematopoietic developmentSemantic proximity Read ↗

Core binding factor at the crossroads: Determining the fate of the HSCSemantic proximity Read ↗

Deletion of core-binding factor β (Cbfβ) in mesenchymal progenitor cells provides new insights into Cbfβ/Runxs complex function in cartilage and bone developmentSemantic proximity Read ↗

Core-binding factor beta interacts with Runx2 and is required for skeletal development.Semantic proximity Read ↗

Core-binding factors in haematopoiesis and leukaemia.Semantic proximity Read ↗

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.Semantic proximity Read ↗

Core binding factor genes and human leukemia.Semantic proximity Read ↗

GATA Transcription Factors: Basic Principles and Related Human Disorders.Semantic proximity Read ↗

Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of <i>ETV6-RUNX1</i> negative B precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

B-lineage transcription factors and cooperating gene lesions required for leukemia development.Semantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.