Article
p53 in breast cancer subtypes and new insights into response to chemotherapy.
Breast (Edinburgh, Scotland) - 1 Aug 2013
Bertheau Philippe, Lehmann-Che Jacqueline, Varna Mariana, Dumay Anne, Poirot Brigitte, Porcher Raphaël, Turpin Elisabeth, Plassa Louis-François, de Roquancourt Anne, Bourstyn Edwige, de Cremoux Patricia, Janin Anne, Giacchetti Sylvie, Espié Marc, de Thé Hugues
Abstract excerpt
Despite an obvious central role of p53 in the hallmarks of cancer, TP53 status is not yet used for the management of breast cancer. Recent findings may lead to reconsider the role of p53 in breast cancer. TP53 mutations are the most frequent genetic alterations in breast cancer, observed in 30% of breast carcinomas. Their distribution is highly linked to molecular tumor subtypes found in 26% of luminal tumors...
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