Article
Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations.
Cell death & disease - 16 Mar 2017
Fulton Joel, Mazumder Bismoy, Whitchurch Jonathan B, Monteiro Cintia J, Collins Hilary M, Chan Chun M, Clemente Maria P, Hernandez-Quiles Miguel, Stewart Elizabeth A, Amoaku Winfried M, Moran Paula M, Mongan Nigel P, Persson Jenny L, Ali Simak, Heery David M
Abstract excerpt
Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the nuclear receptor (NR) superfamily of transcription factors. We assessed the ability of these NRs to form heterodimers with other members of the human NRs representing all major subgroups. The TLX ligand-binding domain (LBD) did not appear...
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