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Article

Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts.

PloS one - 1 Jan 2013

Suzuki Ayako, Mimaki Sachiyo, Yamane Yuki, Kawase Akikazu, Matsushima Koutatsu, Suzuki Makito, Goto Koichi, Sugano Sumio, Esumi Hiroyasu, Suzuki Yutaka, Tsuchihara Katsuya

Abstract excerpt

We analyzed whole-exome sequencing data from 97 Japanese lung adenocarcinoma patients and identified several putative cancer-related genes and pathways. Particularly, we observed that cancer-related mutation patterns were significantly different between different ethnic groups. As previously reported, mutations in the EGFR gene were characteristic to Japanese, while those in the KRAS gene were more frequent in...

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Identifiers

PMID: 24069199
DOI: 10.1371/journal.pone.0073484
PMCID: PMC3772023

Genes

ATM
EGFR
KRAS
PAPPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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