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Comparison of gene mutation profile in different lung adenocarcinoma subtypes by targeted next-generation sequencing.

Medical oncology (Northwood, London, England) - 8 Nov 2023

Zhang Shaowen, Dong Ping, Pan Zongwei, Chen Qian, Zhu Junqi, Mao Zhangfan

Abstract excerpt

BACKGROUND: Disease prognosis after resection of lung cancer could be affected by pathological subtypes. In this study, we investigated the difference of gene variation and significantly altered pathways between adenocarcinoma in situ (AIS)/microinvasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) subtypes to reveal the molecular mechanism of prognosis differences. METHODS: Sixty one tumor tissues were...

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PMID: 37935925
DOI: 10.1007/s12032-023-02206-3

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