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Article

Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1.

Pflugers Archiv : European journal of physiology - 1 May 2014

Wu Minghua, Obara Yutaro, Norota Ikuo, Nagasawa Yoshinobu, Ishii Kuniaki

Abstract excerpt

Abnormal QT prolongation in diabetic patients has become a clinical problem because it increases the risk of lethal ventricular arrhythmia. In an animal model of type 1 diabetes mellitus, several ion currents, including the slowly activating delayed rectifier potassium current (IKs), are altered. The IKs channel is composed of KCNQ1 and KCNE1 subunits, whose genetic mutations are well known to cause long QT...

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Source

Identifiers

PMID: 24068254
DOI: 10.1007/s00424-013-1352-7

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1.PMID 24068254Read ↗

Insights into Cardiac IKs (KCNQ1/KCNE1) Channels RegulationSemantic proximity Read ↗

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3Semantic proximity Read ↗

BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).Semantic proximity Read ↗

Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V.Semantic proximity Read ↗

KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity.Semantic proximity Read ↗

The auxiliary subunit KCNE1 regulates KCNQ1 channel response to sustained calcium-dependent PKC activation.Semantic proximity Read ↗

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.Semantic proximity Read ↗

Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes.Semantic proximity Read ↗

Inhibition of the formation or action of angiotensin II reverses attenuated K+ currents in type 1 and type 2 diabetes.Semantic proximity Read ↗

The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cellsSemantic proximity Read ↗

Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit.Semantic proximity Read ↗

Calbindin-D(28k) controls [Ca(2+)](i) and insulin release. Evidence obtained from calbindin-d(28k) knockout mice and beta cell lines.Semantic proximity Read ↗

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