Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3

1 Aug 2019

Abstract excerpt

Abstract Excessive activation of the NLRP3 inflammasome is a key component contributing to the pathogenesis of various inflammatory diseases. However, the molecular mechanisms underlying its activation and regulation remain poorly defined. The objective of this study was to explore the possible function of the K+ channel pore-forming subunit Kir6.1 in regulating NLRP3 inflammasome activation and insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gout, Hyperuricemia, Uric Acid
Share to Heme Oxygenase-1 and Carbon Monoxide
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31387986
DOI: 10.1038/s12276-019-0291-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3PMID 31387986Read ↗

Emerging Role of LncRNA Regulation for NLRP3 Inflammasome in Diabetes ComplicationsSemantic proximity Read ↗

Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitusSemantic proximity Read ↗

Role of the NLRP3 inflammasome in diabetes and its complications (Review)Semantic proximity Read ↗

Negative regulation of NLRP3 inflammasome signalingSemantic proximity Read ↗

Regulation of inflammasome activation.Semantic proximity Read ↗

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.Semantic proximity Read ↗

Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical PathwaysSemantic proximity Read ↗

Emerging Roles of Inflammasomes in Cardiovascular DiseasesSemantic proximity Read ↗

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteriesSemantic proximity Read ↗

The inflammasome in pathogen recognition and inflammationSemantic proximity Read ↗

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectivesSemantic proximity Read ↗

NLRP3 Inflammasome and Inflammatory DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.