Article
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.
PloS one - 1 Jan 2013
Hanna Megan C, Go Christina, Roden Christine, Jones Robert T, Pochanard Panisa, Javed Ahmed Yasir, Javed Awais, Mondal Chandrani, Palescandolo Emanuele, Van Hummelen Paul, Hatton Charles, Bass Adam J, Chun Sung Min, Na Deuk Chae, Kim Tae-Im, Jang Se Jin, Osarogiagbon Raymond U, Hahn William C, Meyerson Matthew, Garraway Levi A, MacConaill Laura E
Abstract excerpt
It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 385 mutations across 33 known cancer genes in colorectal cancer DNA from 83 Asian, 149 Black and 195 White patients....
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