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Article

Colorectal Tumors in Diverse Patient Populations Feature a Spectrum of Somatic Mutational Profiles.

Cancer research - 15 May 2025

Matejcic Marco, Teer Jamie K, Hoehn Hannah J, Diaz Diana B, Shankar Kritika, Gong Jun, Nguyen Nathalie T, Loroña Nicole C, Coppola Domenico, Fulmer Clifton G, Saglam Ozlen, Jiang Kun, Cress W Douglas, Muñoz-Antonia Teresita, Flores Idhaliz, Gordián Edna R, Oliveras Torres José A, Felder Seth I, Sanchez Julian, Fleming Jason B, Siegel Erin M, Freedman Jennifer A, Dutil Julie, Stern Mariana C, Fridley Brooke L, Figueiredo Jane C, Schmit Stephanie L

Abstract excerpt

Admixed populations, including the Hispanic/Latino/a community, are underrepresented in cancer genetic/genomic studies. Leveraging the Latino Colorectal Cancer Consortium (LC3) and other existing datasets, we analyzed whole-exome sequencing data on tumor/normal pairs from 718 individuals with colorectal cancer to map somatic mutational features by ethnicity and genetic similarity. Global proportions of African,...

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Identifiers

PMID: 40126181
DOI: 10.1158/0008-5472.CAN-24-0747
PMCID: PMC12234169

Genes

KRAS
IMPACT
APC
CDC27
KNCN
PIK3CA
SMAD2
TMEM184B
TP53

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