Article
Distinct clinical and genomic profiles of braf mutation subtypes in Chinese colorectal cancer: a retrospective cohort study with cross-population validation.
Cellular oncology (Dordrecht, Netherlands) - 16 Mar 2026
Yang Wentao, Duan Yi, Huang Xiao, Song Wang, Qian Jingyi, Zeng Yiwei, Guo TianAn, Wu Yunyu, Li Hong, Zou Xuan, Xu Ye
Abstract excerpt
PURPOSE: To characterize the clinicogenomic features, prognostic significance and therapeutic implications of BRAF mutation subtypes in Chinese colorectal cancer (CRC) patients. METHODS: We performed integrated genomic and clinical analyses on 146 BRAF-mutant colorectal cancers identified within a cohort of 2,446 consecutive CRC patients at Fudan University Shanghai Cancer Center (FUSCC) encompassing surgical,...
Topics
- Aged
- Female
- Humans
- Male
- Middle Aged
- Cell Line, Tumor
- China
- Colorectal Neoplasms
- Genomics
- Mutation
- Prognosis
- Proto-Oncogene Proteins B-raf
- Retrospective Studies
- East Asian People