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Distinct clinical and genomic profiles of braf mutation subtypes in Chinese colorectal cancer: a retrospective cohort study with cross-population validation.

Cellular oncology (Dordrecht, Netherlands) - 16 Mar 2026

Yang Wentao, Duan Yi, Huang Xiao, Song Wang, Qian Jingyi, Zeng Yiwei, Guo TianAn, Wu Yunyu, Li Hong, Zou Xuan, Xu Ye

Abstract excerpt

PURPOSE: To characterize the clinicogenomic features, prognostic significance and therapeutic implications of BRAF mutation subtypes in Chinese colorectal cancer (CRC) patients. METHODS: We performed integrated genomic and clinical analyses on 146 BRAF-mutant colorectal cancers identified within a cohort of 2,446 consecutive CRC patients at Fudan University Shanghai Cancer Center (FUSCC) encompassing surgical,...

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Identifiers

PMID: 41838250
DOI: 10.1007/s13402-026-01185-7
PMCID: PMC12992859

Genes

BRAF
TP53

Variants

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