Article
Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon.
The American journal of tropical medicine and hygiene - 1 Oct 1991
Peterson D S, Di Santi S M, Povoa M, Calvosa V S, Do Rosario V E, Wellems T E
Abstract excerpt
Pyrimethamine resistance in cultivated laboratory isolates of Plasmodium falciparum is linked to the dihydrofolate reductase mutation Asn-108, a mutation that acts by interrupting drug binding within the active site of the enzyme. To determine the prevalence of this mutation in endemic regions harboring pyrimethamine-resistant malaria, we used a mutation-specific polymerase chain reaction assay to survey P....
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