Article
Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon.
The American journal of tropical medicine and hygiene - 1 Oct 1991
Peterson D S, Di Santi S M, Povoa M, Calvosa V S, Do Rosario V E, Wellems T E
Abstract excerpt
Pyrimethamine resistance in cultivated laboratory isolates of Plasmodium falciparum is linked to the dihydrofolate reductase mutation Asn-108, a mutation that acts by interrupting drug binding within the active site of the enzyme. To determine the prevalence of this mutation in endemic regions ha...
Topics
- Animals
- Base Sequence
- Brazil
- Codon
- DNA, Protozoan
- Drug Resistance
- Erythrocytes
- Humans
- Molecular Sequence Data
- Mutation
- Plasmodium falciparum
- Polymerase Chain Reaction
- Pyrimethamine
- Tetrahydrofolate Dehydrogenase