Article
Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.
Cell cycle (Georgetown, Tex.) - 1 Sept 2006
Eyal Allon, Engelender Simone
Abstract excerpt
A common finding in many neurodegenerative diseases is the presence of inclusion bodies made of aggregated proteins in neurons of affected brain regions. In Parkinson's disease, the inclusion bodies are referred to as Lewy bodies and their main component is alpha-synuclein. Although many studies have suggested that inclusion bodies may be cell protective, it is still not clear whether Lewy bodies promote or...
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