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Article

Comparison of helix stability in wild-type and mutant LamB signal sequences.

The Journal of biological chemistry - 5 Mar 1990

Bruch M D, Gierasch L M

Abstract excerpt

Previous studies of isolated peptides corresponding to the wild-type signal sequence of the LamB protein of Escherichia coli and to several export-impaired mutants demonstrated that a high tendency to adopt an alpha-helical conformation in low dielectric environments was a property of functional sequences. We have now used nuclear magnetic resonance to establish further characteristics of the helical conformation...

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PMID: 2406265

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