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Article

Positional dependence of non-native polar mutations on folding of CFTR helical hairpins.

Biochimica et biophysica acta - 1 Jan 2008

Wehbi Hania, Gasmi-Seabrook Geneviève, Choi Mei Y, Deber Charles M

Abstract excerpt

Mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) cause CF disease by altering the biosynthesis, maturation, folding and ion conductance of this protein. Our laboratory has focused on expression and structural analysis of the CFTR transmembrane (TM) domains using two-TM segments (i.e., helix-loop-helix constructs) which we term 'helical hairpins'; these represent the minimal model of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17949679
DOI: 10.1016/j.bbamem.2007.08.036

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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