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Article

Signal sequence mutations as tools for the characterization of LamB folding intermediates.

Journal of bacteriology - 1 Dec 2002

Duguay Amy Rizzitello, Silhavy Thomas J

Abstract excerpt

lamBA23DA25Y and lamBA23YA25Y tether LamB to the inner membrane by blocking signal sequence processing. We isolated suppressors of lamBA23DA25Y and lamBA23YA25Y, all of which mapped within the LamB signal sequence. Most interesting were mutations that changed an amino acid with a strong positive charge to an amino acid with no charge. Further characterization of two such suppressors revealed that they produce...

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Identifiers

PMID: 12446642
DOI: 10.1128/JB.184.24.6918-6928.2002
PMCID: PMC135451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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