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Article

Structural studies on peptides corresponding to mutants of the major alpha-helix of barnase.

Biochemistry - 23 Aug 1994

Kippen A D, Arcus V L, Fersht A R

Abstract excerpt

The structures of a family of peptides that contain variants of the major alpha-helix of barnase (residues 6-18) have been analyzed in solution by circular dichroism (CD) and 1H NMR at various concentrations of the helix-inducing cosolvent trifluoroethanol (TFE). The very low equilibrium constant (approximately 10(-2) for the formation of helix in water KH2O was estimated from titration of the helical ellipticity...

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Identifiers

PMID: 8060969
DOI: 10.1021/bi00199a027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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