Article
Is modification sufficient to protect a bacterial chromosome from a resident restriction endonuclease?
Molecular microbiology - 1 Jan 2004
Makovets Svetlana, Powell Lynn M, Titheradge Annette J B, Blakely Garry W, Murray Noreen E
Abstract excerpt
It has been generally accepted that DNA modification protects the chromosome of a bacterium encoding a restriction and modification system. But, when target sequences within the chromosome of one such bacterium (Escherichia coli K-12) are unmodified, the cell does not destroy its own DNA; instead, ClpXP inactivates the nuclease, and restriction is said to be alleviated. Thus, the resident chromosome is recognized...
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