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Article

The enzymatic basis of processivity in lambda exonuclease.

Nucleic acids research - 15 Mar 2003

Subramanian Krithika, Rutvisuttinunt Wiriya, Scott Walter, Myers Richard S

Abstract excerpt

Lambda exonuclease is a highly processive 5'-->3' exonuclease that degrades double-stranded (ds)DNA. The single-stranded DNA produced by lambda exonuclease is utilized by homologous pairing proteins to carry out homologous recombination. The extensive studies of lambda biology, lambda exonuclease enzymology and the availability of the X-ray crystallographic structure of lambda exonuclease make it a suitable model...

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Identifiers

PMID: 12626699
DOI: 10.1093/nar/gkg266
PMCID: PMC152868

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