A novel specific pyrosequencing method for genotyping FCGR3A rs396991 without coamplification of homologous gene FCGR3B.

doi:10.1097/FPC.0b013e328365a4f2

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Article

A novel specific pyrosequencing method for genotyping FCGR3A rs396991 without coamplification of homologous gene FCGR3B.

Pharmacogenetics and genomics - 1 Nov 2013

van der Straaten Tahar, Martijn Richender, el Hajoui Toufik, Baak-Pablo Renee, Guchelaar Henk-Jan

Abstract excerpt

Monoclonal antibodies, such as rituximab, trastuzumab, and cetuximab, mediate immune response by binding to Fcγ receptors. The frequently occurring Phe158Val variant of the FCGR3A gene has increased binding affinity and consequently may affect immune response. Several pharmacogenetic association studies have genotyped this variant (FCGR3A rs396991), but with disconcordant results. In addition, in some of these...

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PMID: 24061201
DOI: 10.1097/FPC.0b013e328365a4f2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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