Article
Studies on the structure and mechanism of H-ras p21.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Apr 1992
Goody R S, Pai E F, Schlichting I, Rensland H, Scheidig A, Franken S, Wittinghofer A
Abstract excerpt
Current knowledge of the structure of H-ras p21 is reviewed with particular emphasis on the interaction between guanine nucleotides and the active site of the protein. The nature of the conformational change induced by GTP hydrolysis is discussed. The major change is seen in the region known as the effector loop (loop 2), with significant but less well-defined changes occurring in loop 4, which is implicated in...
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