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Article

Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.

PloS one - 1 Jan 2013

Yang Xiaoping, La Rosa Francisco G, Genova Elizabeth Erin, Huber Kendra, Schaack Jerome, Degregori James, Serkova Natalie J, Li Yuan, Su Lih-Jen, Kessler Elizabeth, Flaig Thomas W

Abstract excerpt

The development of the Cre recombinase-controlled (Cre/LoxP) technique allows the manipulation of specific tumorigenic genes, temporarily and spatially. Our original intention of this study was to investigate the role of Kras and p53 in the development of urinary bladder cancer. First, to validate the effect of intravesical delivery on Cre recombination (Adeno-Cre), we examined activity and expression of...

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Identifiers

PMID: 24058630
DOI: 10.1371/journal.pone.0074809
PMCID: PMC3776760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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