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Article

Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice.

PloS one - 1 Jan 2021

Walcheck Morgan T, Matkowskyj Kristina A, Turco Anne, Blaine-Sauer Simon, Nukaya Manabu, Noel Jessica, Ronnekleiv Oline K, Ronnekleiv-Kelly Sean M

Abstract excerpt

Anal squamous cell carcinoma (SCC) will be diagnosed in an estimated 9,080 adults in the United States this year, and rates have been rising over the last several decades. Most people that develop anal SCC have associated human papillomavirus (HPV) infection (~85-95%), with approximately 5-15% of anal SCC cases occurring in HPV-negative patients from unknown etiology. This study identified and characterized the...

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Share to Anus Neoplasms
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34735515
DOI: 10.1371/journal.pone.0259245
PMCID: PMC8568287

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