Article
Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis.
Cell death & disease - 3 Mar 2011
Ahmad I, Patel R, Liu Y, Singh L B, Taketo M M, Wu X-R, Leung H Y, Sansom O J
Abstract excerpt
Mutations in the Ras family of proteins (predominantly in H-Ras) occur in approximately 40% of urothelial cell carcinoma (UCC). However, relatively little is known about subsequent mutations/pathway alterations that allow tumour progression. Indeed, expressing mutant H-Ras within the mouse bladder does not lead to tumour formation, unless this is expressed at high levels. The Wnt signalling pathway is deregulated...
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