Article
IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2015
Chen Xin, Willette-Brown Jami, Wu Xueqiang, Hu Ya, Howard O M Zack, Hu Yinling, Oppenheim Joost J
Abstract excerpt
It was reported that TNF receptor type II signaling, which has the capacity to stimulate CD4+ forkhead box P3+ (Foxp3+) regulatory T cells (Tregs), activated the noncanonical NF-κB pathway in an IKKα-dependent manner. Therefore, we studied the role of IKKα in the homeostasis of Treg population. To this end, we generated a mouse strain with conditional knockout of IKKα in CD4 cells (Ikkα(f/f):CD4.Cre) that showed...
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