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Article

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.

The Journal of biological chemistry - 14 Oct 2005

Tudor Elizabeth L, Perkinton Michael S, Schmidt Anja, Ackerley Steven, Brownlees Janet, Jacobsen Nicholas J O, Byers Helen L, Ward Malcolm, Hall Alan, Leigh P Nigel, Shaw Christopher E, McLoughlin Declan M, Miller Christopher C J

Abstract excerpt

Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine nucleotide exchange factors (GEFs) that promote GDP release and GTP binding. ALS2/Alsin is a recently described GEF that contains a central domain that is predicted to regulate the activities of Rac...

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Source

Identifiers

PMID: 16049005
DOI: 10.1074/jbc.M506216200

Genes

ALS2
PAK1

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.PMID 16049005Read ↗

Alsin and the molecular pathways of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome traffickingSemantic proximity Read ↗

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.Semantic proximity Read ↗

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.Semantic proximity Read ↗

Amyotrophic Lateral Sclerosis 2-Deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis through Altered AMPA Receptor TraffickingSemantic proximity Read ↗

Anti-ALS activity of alsin, the product of the ALS2 gene, and activity-dependent neurotrophic factor.Semantic proximity Read ↗

Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.Semantic proximity Read ↗

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.Semantic proximity Read ↗

Rac GTPases control axon growth, guidance and branching.Semantic proximity Read ↗

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.Semantic proximity Read ↗

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