Article
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.
Nature cell biology - 1 Apr 2017
Lilja Johanna, Zacharchenko Thomas, Georgiadou Maria, Jacquemet Guillaume, De Franceschi Nicola, Peuhu Emilia, Hamidi Hellyeh, Pouwels Jeroen, Martens Victoria, Nia Fatemeh Hassani, Beifuss Malte, Boeckers Tobias, Kreienkamp Hans-Juergen, Barsukov Igor L, Ivaska Johanna
Abstract excerpt
SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of the SHANK3 N-terminal region revealed that the SPN domain is an unexpected Ras-association domain with high affinity for GTP-bound Ras and Rap G-proteins. The role of Rap1 in integrin activation is well established but the mechanisms to...
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