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Article

Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK).

Journal of pediatric surgery - 1 Jun 2022

Bownes Laura V, Marayati Raoud, Quinn Colin H, Hutchins Sara C, Stewart Jerry E, Anderson Joshua C, Willey Christopher D, Datta Pran K, Beierle Elizabeth A

Abstract excerpt

BACKGROUND: Serine-threonine kinase receptor associated protein (STRAP), a scaffolding protein, is upregulated in many solid tumors. As such, we hypothesized that STRAP may be overexpressed in neuroblastoma tumors and may play a role in neuroblastoma tumor progression. METHODS: We examined two publicly available neuroblastoma patient databases, GSE49710 (n = 498) and GSE49711 (n = 498), to investigate STRAP...

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Identifiers

PMID: 35272839
DOI: 10.1016/j.jpedsurg.2022.01.064
PMCID: PMC9119921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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