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Article

The association of endothelial nitric oxide synthase gene single nucleotide polymorphisms with paediatric systemic lupus erythematosus.

Clinical and experimental rheumatology - 1 Jan 2000

Zhu Jia, Wang Zhen, Song Guowei, Zhang Ting, Wang Li, Wu Fengqi

Abstract excerpt

OBJECTIVES: Endothelial nitric oxide synthase (eNOS) is a type of nitric oxide synthase that mainly exists in the endothelium. It produces nitric oxide (NO) to regulate the function of endothelial cells. Endothelial dysfunction and increased NO metabolites have been shown in animal models of lupus and in lupus patients, so eNOS gene polymorphisms may be important in the pathogenesis of SLE. This study aimed to...

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PMID: 29465350

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