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Article

Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae.

Science (New York, N.Y.) - 26 Jan 1990

Field J, Xu H P, Michaeli T, Ballester R, Sass P, Wigler M, Colicelli J

Abstract excerpt

The interaction between RAS proteins and adenylyl cyclase was studied by using dominant interfering mutations of adenylyl cyclase from the yeast Saccharomyces cerevisiae. RAS proteins activate adenylyl cyclase in this organism. A plasmid expressing a catalytically inactive adenylyl cyclase was found to interfere dominantly with this activation. The interfering region mapped to the leucine-rich repeat region of...

Topics

Adenylyl Cyclases
Codon
Deoxyribonucleases, Type II Site-Specific
Escherichia coli
Fungal Proteins
Genes, Fungal
Leucine
Mutation
Plasmids
Repetitive Sequences, Nucleic Acid
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Nucleic Acid

Transformation, Genetic

ras Proteins

Source

Identifiers

PMID: 2405488
DOI: 10.1126/science.2405488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2405488-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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