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Article

Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.

Nature biotechnology - 1 Sept 1999

Cismowski M J, Takesono A, Ma C, Lizano J S, Xie X, Fuernkranz H, Lanier S M, Duzic E

Abstract excerpt

We describe genetic screens in Saccharomyces cerevisiae designed to identify mammalian nonreceptor modulators of G-protein signaling pathways. Strains lacking a pheromone-responsive G-protein coupled receptor and expressing a mammalian-yeast Galpha hybrid protein were made conditional for growth upon either pheromone pathway activation (activator screen) or pheromone pathway inactivation (inhibitor screen)....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10471929
DOI: 10.1038/12867

Genes

RGS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.PMID 10471929Read ↗

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